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KMID : 0605720170230020095
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Journal of the Korean Society of Biological Therapies in Psychiatry
2017 Volume.23 No. 2 p.95 ~ p.107
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Alteration of Olfactory Function and Cognitive Function after Chemotherapy in Patients with Breast Cancer : A Preliminary Study
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Lim Jong-Seok
Koh Su-Jin
Joe Soo-Hyun
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Abstract
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Objectives：This study evaluated olfactory identification performance and cognitive impairment following chemotherapy in patients with breast cancer.
Methods：A total of 18 patients with breast cancer who were treated with chemotherapy were included in this study. The patients were evaluated for mental status, cognitive function, and olfactory identification performance before chemotherapy and 6 months after chemotherapy. Paired t-tests were used to examine the differences in scores before and after chemotherapy sessions.
Results：No statistically significant differences were found in the scores of subjective cognitive function and olfactory identification performance pre- and post- chemotherapy. None of the objective cognitive function test scores declined at 6 months after chemotherapy. Mean scores of word list delayed recall(p=0.011), trail making A(p=0.026), symbol search(p=0.032), and modified Stroop test(p=0.002) showed significant improvement after chemotherapy. Among them, modified Stroop test score showed statistically significant improvement after Bonferroni correction.
Conclusion：Olfactory and subjective cognitive functions of patients were not impaired 6 months after chemotherapy. However, some cognitive function related to execution improved 6 months after chemotherapy. These improvements in cognitive function after chemotherapy could be due to either a practice effect, recovery from acute stress due to cancer treatment, or an anti-inflammatory effect of chemotherapy. It is necessary to study the persistence of this pattern of cognitive improvement in long term follow-up.
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KEYWORD
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Cognition, Olfactory perception, Breast neoplasms, Adjuvant chemotherapy
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